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Metabolic syndrome in Argentinean patients with systemic lupus erythematosus

Identifieur interne : 001850 ( Main/Exploration ); précédent : 001849; suivant : 001851

Metabolic syndrome in Argentinean patients with systemic lupus erythematosus

Auteurs : V. Bellomio [Argentine] ; A. Spindler [Argentine] ; E. Lucero [Argentine] ; A. Berman [Argentine] ; R. Sueldo [Argentine] ; H. Berman [Argentine] ; M. Santana [Argentine] ; Mj Molina [Argentine] ; V. G Ngora [Argentine] ; G. Cassano [Argentine] ; S. Paira [Argentine] ; V. Saurit [Argentine] ; G. Retamozo [Argentine] ; A. Alvarellos [Argentine] ; F. Caerio [Argentine] ; P. Alba [Argentine] ; M. Gotero [Argentine] ; Ej Velozo [Argentine] ; F. Ceballos [Argentine] ; E. Soriano [Argentine] ; L. Catoggio [Argentine] ; Ma García [Argentine] ; A. Eimon [Argentine] ; S. Agüero [Argentine] ; V. Bellomio ; A. Spindler ; E. Lucero ; A. Berman ; R. Sueldo ; H. Berman ; M. Santana ; Mj Molina ; V. G Ngora ; G. Cassano ; S. Paira ; V. Saurit ; G. Retamozo ; A. Alvarellos ; F. Caerio ; P. Alba ; M. Gotero ; Ej Velozo ; F. Ceballos ; E. Soriano ; L. Catoggio ; Ma García ; A. Eimon ; S. Agüero

Source :

RBID : ISTEX:DF9499CCCF052996E8E74601EA4542A5C1866B4E

Descripteurs français

English descriptors

Abstract

The objective was to determine the prevalence of the metabolic syndrome (MS) in patients with systemic lupus erythematosus (SLE) in Argentina, to assess the factors associated to it, and to compare the results with a control group with non-inflammatory disorders. The study included 147 patients with SLE and 119 controls. MS was defined according to criteria by the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) Scientific Statement. Demographic characteristics, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI) were assessed as well as administration, maximum dose and cumulative dose of prednisone and hydroxychloroquine (HCQ). MS prevalence was 28.6% (CI 95%: 21.4–36.6) in patients with SLE and 16% in controls (P = 0.0019). Patients with SLE presented higher arterial hypertension frequency compared with controls (43 vs 25%, P = 0.007). When comparing lupus patients with MS (n = 41) and without MS (n = 106), no significant differences were observed regarding duration of the disease, SLEDAI or cumulative prednisone dose. Cumulative damage was associated independently with MS (OR 1.98; P = 0.021), whereas HCQ use was found to be protective (OR 0.13; P = 0.015). Patients with lupus presented higher MS prevalence than controls with non-inflammatory disorders, and occurrence of arterial hypertension was also higher. MS was associated with cumulative damage; the use of HCQ showed to be protective against presence of MS.

Url:
DOI: 10.1177/0961203309105876


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<name sortKey="Eimon, A" sort="Eimon, A" uniqKey="Eimon A" first="A" last="Eimon">A. Eimon</name>
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<country xml:lang="fr">Argentine</country>
<wicri:regionArea>CEMIC, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author wicri:is="90%">
<name sortKey="Aguero, S" sort="Aguero, S" uniqKey="Aguero S" first="S" last="Agüero">S. Agüero</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Sanatorio Pasteur, Catamarca</wicri:regionArea>
<wicri:noRegion>Catamarca</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Bellomio, V" sort="Bellomio, V" uniqKey="Bellomio V" first="V" last="Bellomio">V. Bellomio</name>
</author>
<author>
<name sortKey="Spindler, A" sort="Spindler, A" uniqKey="Spindler A" first="A" last="Spindler">A. Spindler</name>
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<author>
<name sortKey="Lucero, E" sort="Lucero, E" uniqKey="Lucero E" first="E" last="Lucero">E. Lucero</name>
</author>
<author>
<name sortKey="Berman, A" sort="Berman, A" uniqKey="Berman A" first="A" last="Berman">A. Berman</name>
</author>
<author>
<name sortKey="Sueldo, R" sort="Sueldo, R" uniqKey="Sueldo R" first="R" last="Sueldo">R. Sueldo</name>
</author>
<author>
<name sortKey="Berman, H" sort="Berman, H" uniqKey="Berman H" first="H" last="Berman">H. Berman</name>
</author>
<author>
<name sortKey="Santana, M" sort="Santana, M" uniqKey="Santana M" first="M" last="Santana">M. Santana</name>
</author>
<author>
<name sortKey="Molina, Mj" sort="Molina, Mj" uniqKey="Molina M" first="Mj" last="Molina">Mj Molina</name>
</author>
<author>
<name sortKey="G Ngora, V" sort="G Ngora, V" uniqKey="G Ngora V" first="V" last="G Ngora">V. G Ngora</name>
</author>
<author>
<name sortKey="Cassano, G" sort="Cassano, G" uniqKey="Cassano G" first="G" last="Cassano">G. Cassano</name>
</author>
<author>
<name sortKey="Paira, S" sort="Paira, S" uniqKey="Paira S" first="S" last="Paira">S. Paira</name>
</author>
<author>
<name sortKey="Saurit, V" sort="Saurit, V" uniqKey="Saurit V" first="V" last="Saurit">V. Saurit</name>
</author>
<author>
<name sortKey="Retamozo, G" sort="Retamozo, G" uniqKey="Retamozo G" first="G" last="Retamozo">G. Retamozo</name>
</author>
<author>
<name sortKey="Alvarellos, A" sort="Alvarellos, A" uniqKey="Alvarellos A" first="A" last="Alvarellos">A. Alvarellos</name>
</author>
<author>
<name sortKey="Caerio, F" sort="Caerio, F" uniqKey="Caerio F" first="F" last="Caerio">F. Caerio</name>
</author>
<author>
<name sortKey="Alba, P" sort="Alba, P" uniqKey="Alba P" first="P" last="Alba">P. Alba</name>
</author>
<author>
<name sortKey="Gotero, M" sort="Gotero, M" uniqKey="Gotero M" first="M" last="Gotero">M. Gotero</name>
</author>
<author>
<name sortKey="Velozo, Ej" sort="Velozo, Ej" uniqKey="Velozo E" first="Ej" last="Velozo">Ej Velozo</name>
</author>
<author>
<name sortKey="Ceballos, F" sort="Ceballos, F" uniqKey="Ceballos F" first="F" last="Ceballos">F. Ceballos</name>
</author>
<author>
<name sortKey="Soriano, E" sort="Soriano, E" uniqKey="Soriano E" first="E" last="Soriano">E. Soriano</name>
</author>
<author>
<name sortKey="Catoggio, L" sort="Catoggio, L" uniqKey="Catoggio L" first="L" last="Catoggio">L. Catoggio</name>
</author>
<author>
<name sortKey="Garcia, Ma" sort="Garcia, Ma" uniqKey="Garcia M" first="Ma" last="García">Ma García</name>
</author>
<author>
<name sortKey="Eimon, A" sort="Eimon, A" uniqKey="Eimon A" first="A" last="Eimon">A. Eimon</name>
</author>
<author>
<name sortKey="Aguero, S" sort="Aguero, S" uniqKey="Aguero S" first="S" last="Agüero">S. Agüero</name>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j">Lupus</title>
<idno type="ISSN">0961-2033</idno>
<idno type="eISSN">1477-0962</idno>
<imprint>
<publisher>SAGE Publications</publisher>
<pubPlace>Sage UK: London, England</pubPlace>
<date type="published" when="2009-10">2009-10</date>
<biblScope unit="volume">18</biblScope>
<biblScope unit="issue">11</biblScope>
<biblScope unit="page" from="1019">1019</biblScope>
<biblScope unit="page" to="1025">1025</biblScope>
</imprint>
<idno type="ISSN">0961-2033</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0961-2033</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Adult</term>
<term>Argentina (epidemiology)</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Lupus Erythematosus, Systemic (physiopathology)</term>
<term>Metabolic Syndrome (epidemiology)</term>
<term>Metabolic Syndrome (physiopathology)</term>
<term>Middle Aged</term>
<term>Regression Analysis</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de régression</term>
<term>Argentine (épidémiologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lupus érythémateux disséminé (physiopathologie)</term>
<term>Études transversales</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Argentina</term>
<term>Metabolic Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr">
<term>Lupus érythémateux disséminé</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Lupus Erythematosus, Systemic</term>
<term>Metabolic Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Argentine</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en">
<term>Adult</term>
<term>Adult treatment panel</term>
<term>American heart association</term>
<term>Antimalarial drugs</term>
<term>Argentina</term>
<term>Argentinean</term>
<term>Argentinean patients</term>
<term>Arterial hypertension</term>
<term>Arthritis rheum</term>
<term>Atherosclerosis</term>
<term>Bellomio</term>
<term>Blood institute</term>
<term>Buenos aires</term>
<term>Cardiovascular disease</term>
<term>Control group</term>
<term>Control patients</term>
<term>Cross-Sectional Studies</term>
<term>Cumulative damage</term>
<term>Cumulative damage score</term>
<term>Cumulative dosage</term>
<term>Cumulative dose</term>
<term>Cumulative time</term>
<term>Damage index</term>
<term>Demographic characteristics</term>
<term>Diabetes mellitus</term>
<term>Disease activity</term>
<term>Disease duration</term>
<term>Drug treatment</term>
<term>Effect plot</term>
<term>Erythematosus</term>
<term>Expert panel</term>
<term>Female</term>
<term>Glucose</term>
<term>High blood cholesterol</term>
<term>High prevalence</term>
<term>Higher frequency</term>
<term>Higher prevalence</term>
<term>Hospital angel padilla</term>
<term>Humans</term>
<term>Hydroxychloroquine</term>
<term>Hydroxychloroquine treatment duration</term>
<term>Hypertension</term>
<term>Hypertension frequency</term>
<term>Independent association</term>
<term>Inflammatory response</term>
<term>Insulin resistance</term>
<term>Logistic regression analysis</term>
<term>Lumina study group</term>
<term>Lupus</term>
<term>Lupus patients</term>
<term>Metabolic</term>
<term>Metabolic syndrome</term>
<term>Methylprednisolone pulse therapy</term>
<term>Middle Aged</term>
<term>National cholesterol education program</term>
<term>National heart</term>
<term>Prednisone treatment duration</term>
<term>Prevalence</term>
<term>Regression Analysis</term>
<term>Rheum</term>
<term>Rheumatoid arthritis</term>
<term>Rheumatology damage index</term>
<term>Risk factors</term>
<term>Significant differences</term>
<term>Sledai</term>
<term>Sledai score</term>
<term>Southern spain</term>
<term>Steroid</term>
<term>Syndrome</term>
<term>Systemic</term>
<term>Systemic lupus</term>
<term>Systemic lupus erythematosus</term>
<term>Systemic lupus erythematosus disease activity index</term>
<term>Therapeutic variables</term>
<term>Third report</term>
<term>Treatment duration</term>
<term>Universidad nacional</term>
<term>Vascular events</term>
<term>Waist circumference</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de régression</term>
<term>Femelle</term>
<term>Humains</term>
<term>Études transversales</term>
</keywords>
</textClass>
<langUsage>
<language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">The objective was to determine the prevalence of the metabolic syndrome (MS) in patients with systemic lupus erythematosus (SLE) in Argentina, to assess the factors associated to it, and to compare the results with a control group with non-inflammatory disorders. The study included 147 patients with SLE and 119 controls. MS was defined according to criteria by the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) Scientific Statement. Demographic characteristics, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI) were assessed as well as administration, maximum dose and cumulative dose of prednisone and hydroxychloroquine (HCQ). MS prevalence was 28.6% (CI 95%: 21.4–36.6) in patients with SLE and 16% in controls (P = 0.0019). Patients with SLE presented higher arterial hypertension frequency compared with controls (43 vs 25%, P = 0.007). When comparing lupus patients with MS (n = 41) and without MS (n = 106), no significant differences were observed regarding duration of the disease, SLEDAI or cumulative prednisone dose. Cumulative damage was associated independently with MS (OR 1.98; P = 0.021), whereas HCQ use was found to be protective (OR 0.13; P = 0.015). Patients with lupus presented higher MS prevalence than controls with non-inflammatory disorders, and occurrence of arterial hypertension was also higher. MS was associated with cumulative damage; the use of HCQ showed to be protective against presence of MS.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Argentine</li>
</country>
</list>
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<name sortKey="Alvarellos, A" sort="Alvarellos, A" uniqKey="Alvarellos A" first="A" last="Alvarellos">A. Alvarellos</name>
<name sortKey="Bellomio, V" sort="Bellomio, V" uniqKey="Bellomio V" first="V" last="Bellomio">V. Bellomio</name>
<name sortKey="Berman, A" sort="Berman, A" uniqKey="Berman A" first="A" last="Berman">A. Berman</name>
<name sortKey="Berman, H" sort="Berman, H" uniqKey="Berman H" first="H" last="Berman">H. Berman</name>
<name sortKey="Caerio, F" sort="Caerio, F" uniqKey="Caerio F" first="F" last="Caerio">F. Caerio</name>
<name sortKey="Cassano, G" sort="Cassano, G" uniqKey="Cassano G" first="G" last="Cassano">G. Cassano</name>
<name sortKey="Catoggio, L" sort="Catoggio, L" uniqKey="Catoggio L" first="L" last="Catoggio">L. Catoggio</name>
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<name sortKey="Spindler, A" sort="Spindler, A" uniqKey="Spindler A" first="A" last="Spindler">A. Spindler</name>
<name sortKey="Sueldo, R" sort="Sueldo, R" uniqKey="Sueldo R" first="R" last="Sueldo">R. Sueldo</name>
<name sortKey="Velozo, Ej" sort="Velozo, Ej" uniqKey="Velozo E" first="Ej" last="Velozo">Ej Velozo</name>
</noCountry>
<country name="Argentine">
<noRegion>
<name sortKey="Bellomio, V" sort="Bellomio, V" uniqKey="Bellomio V" first="V" last="Bellomio">V. Bellomio</name>
</noRegion>
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<name sortKey="Alvarellos, A" sort="Alvarellos, A" uniqKey="Alvarellos A" first="A" last="Alvarellos">A. Alvarellos</name>
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<name sortKey="Berman, H" sort="Berman, H" uniqKey="Berman H" first="H" last="Berman">H. Berman</name>
<name sortKey="Caerio, F" sort="Caerio, F" uniqKey="Caerio F" first="F" last="Caerio">F. Caerio</name>
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<name sortKey="Catoggio, L" sort="Catoggio, L" uniqKey="Catoggio L" first="L" last="Catoggio">L. Catoggio</name>
<name sortKey="Ceballos, F" sort="Ceballos, F" uniqKey="Ceballos F" first="F" last="Ceballos">F. Ceballos</name>
<name sortKey="Eimon, A" sort="Eimon, A" uniqKey="Eimon A" first="A" last="Eimon">A. Eimon</name>
<name sortKey="G Ngora, V" sort="G Ngora, V" uniqKey="G Ngora V" first="V" last="G Ngora">V. G Ngora</name>
<name sortKey="Garcia, Ma" sort="Garcia, Ma" uniqKey="Garcia M" first="Ma" last="García">Ma García</name>
<name sortKey="Gotero, M" sort="Gotero, M" uniqKey="Gotero M" first="M" last="Gotero">M. Gotero</name>
<name sortKey="Lucero, E" sort="Lucero, E" uniqKey="Lucero E" first="E" last="Lucero">E. Lucero</name>
<name sortKey="Molina, Mj" sort="Molina, Mj" uniqKey="Molina M" first="Mj" last="Molina">Mj Molina</name>
<name sortKey="Paira, S" sort="Paira, S" uniqKey="Paira S" first="S" last="Paira">S. Paira</name>
<name sortKey="Retamozo, G" sort="Retamozo, G" uniqKey="Retamozo G" first="G" last="Retamozo">G. Retamozo</name>
<name sortKey="Santana, M" sort="Santana, M" uniqKey="Santana M" first="M" last="Santana">M. Santana</name>
<name sortKey="Saurit, V" sort="Saurit, V" uniqKey="Saurit V" first="V" last="Saurit">V. Saurit</name>
<name sortKey="Soriano, E" sort="Soriano, E" uniqKey="Soriano E" first="E" last="Soriano">E. Soriano</name>
<name sortKey="Spindler, A" sort="Spindler, A" uniqKey="Spindler A" first="A" last="Spindler">A. Spindler</name>
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<name sortKey="Velozo, Ej" sort="Velozo, Ej" uniqKey="Velozo E" first="Ej" last="Velozo">Ej Velozo</name>
</country>
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</affiliations>
</record>

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